Nature Medicine Publication Highlights use of the GeoMx Digital Spatial Profiler

SEATTLE, July 23, 2019 (GLOBE NEWSWIRE) — In a release issued the day past by using NanoString Technologies, Inc. (NSTG) underneath the identical headline; please word that within the third paragraph Dr. Justin Balko’s name has been revised. The complete corrected textual content follows:

NanoString Technologies, Inc. (NSTG), a issuer of life technology gear for translational research and molecular diagnostic merchandise, today announced the booklet of a take a look at in the journal Nature Medicine that demonstrates the functionality of the GeoMx™ Digital Spatial Profiler (DSP) to signify toxicities related to immunotherapy the use of checkpoint inhibitors.

While checkpoint inhibitors can cause durable responses in more than a few metastatic cancers, unanticipated immune-related detrimental activities can restrict the software of these lifestyles-saving therapies. A group of researchers led with the aid of Dr. Justin Balko lately published a study entitled “A case file of clonal EBV-like reminiscence CD4+ T cell activation in deadly checkpoint inhibitor induced encephalitis.” In this situation record, investigators used the GeoMx DSP to represent immune infiltrates within the mind of a patient who passed faraway from neurotoxicity following immunotherapy remedy for metastatic cancer. The Geox DSP revealed the presence of activated T cells inside the infected, non-tumor-containing area of the brain. These T cells were characterized by other structures and found to be potentially unique for Epstein Barr Virus-associated proteins. Geox DSP profiling of non-inflamed areas from the equal affected person, as well as sufferers with other forms of encephalitis, did now not display proof of activated T cells, suggesting that populace turned into specific to the inflamed location within the immunotherapy dealt with the affected person.

“We elected to represent the samples from this affected person with the GeoMx DSP because the patient tissue became confined and was preserved in FFPE. The Geox platform enabled high-plex characterization that might now not had been feasible on other structures,” said Justin Balko, Pharm.D., Ph.D., Department of Medicine, Vanderbilt University Medical Center. “We used the statistics we acquired from the DSP to guide our other profiling of the affected person and in doing so, discover new biology at the back of checkpoint inhibitor-precipitated neurotoxicity.”

“This examine is the sixth peer-reviewed book to highlight the importance of spatial profiling for characterizing mechanisms of movement and toxicity of immunotherapies, which might also ultimately bring about progressed treatment alternatives for sufferers,” said Brad Gray, NanoString’s president and CEO.

The information for this publication turned into generated as part of a collaboration with NanoString Technologies, and samples are processed at NanoString using a prototype GeoMx Digital Spatial Profiler.

The GeoMx Digital Spatial Profiler allows researchers to hastily and quantitatively characterize tissue morphology with a high-throughput, excessive-plex RNA and protein profiling gadget that preserves samples for future analyses. NanoString and its collaborators have offered DSP data in greater than 25 abstracts at fundamental clinical meetings, demonstrating the utility of DSP era to deal with a huge range of organic questions in Formalin-Fixed Paraffin-Embedded (FFPE) tissues.

About NanoString Technologies, Inc.

NanoString Technologies is a leading provider of existence technological know-how equipment for translational studies and molecular diagnostic products. The organization’s nCounter® Analysis System is utilized in lifestyles sciences research and has been noted in more than 2,650 peer-reviewed publications. The nCounter Analysis System offers a price-powerful way to without difficulty profile the expression of hundreds of genes, proteins, miRNAs, or copy range versions, concurrently with excessive sensitivity and precision, facilitating a huge type of simple research and translational medicine applications, including biomarker discovery and validation. The company’s GeoMx™ Digital Spatial Profiler enables exceptionally-multiplexed spatial profiling of RNA and protein goals in a variety of pattern sorts, along with FFPE tissue sections. The enterprise’s era is likewise being utilized in diagnostics. The Prosigna® Breast Cancer Prognostic Gene Signature Assay collectively with the nCounter Dx Analysis System is FDA 510(ok) cleared to be used as a prognostic indicator for remote recurrence of breast most cancers.

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